NFL WEEK 16 2021 PREDICTIONS & PICKS
16 GAMESUPDATED JUL 4, 2026
THE SHORT ANSWER
NoPunt went 10-6 straight up in Week 16 2021.
The most confident pick, the Tampa Bay Buccaneers at 67%, won 32-6.
Our most confident Week 16 pick is the Tampa Bay Buccaneers over the Carolina Panthers, at 67% win probability.
7 of 16 games on the Week 16 slate are effective coin flips, under 55% win probability.
Before kickoff
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WHAT WE GOT WRONG
Our highest-probability miss this week: the Los Angeles Chargers at 66% win probability lost 29-41.
The C-tier underperformed its historical hit rate this week: 2-3 (40%) against a 59% all-time rate.
PROEvery pick's read, side, tier, win probability, spread, is free. The Edge (the games we flag as bets) and Kelly sizing are Pro.
FILTER
QUESTIONS
Our safest Week 16 2021 pick is the Tampa Bay Buccaneers over the Carolina Panthers, at 67% win probability.
7 of 16 games in Week 16 2021 are effective coin flips on our model, under 55% win probability.
NoPunt's model picks every game of Week 16, 2021, tier-graded from S (strongest) to C, with a win probability, predicted margin and spread for each. See the full slate on this page.
NoPunt went 10-6 straight up in Week 16 2021.
Our highest-probability miss this week: the Los Angeles Chargers at 66% win probability lost 29-41. The C-tier underperformed its historical hit rate this week: 2-3 (40%) against a 59% all-time rate.